Progress of m6A Methylation in Lipid Metabolism in Humans and Animals

N6-methyladenosine (m6A) methylation is a type of modification discovered on RNA molecules, mainly mRNAs, as well other RNAs. Similar to DNA methylation, m6A regulates the post-transcriptional expression level genes without altering their base sequences. It modulates gene by affecting binding mRNAs reader proteins, thereby regulating variable splicing, translation efficiency, and stability mRNAs. Early in research, study m6A-related biological functions was greatly hindered due lack effective detection methods. As second-generation sequencing bioinformatics develop, several methods have been available detect predict sites recent years. Moreover, also closely related development lipid metabolism, shown current studies. Combined with this paper reviews concept, detection, prediction means especially relationship between providing new clue enrich molecular mechanism metabolism.